By Donald Heath DSc, MD, PhD, FRCP, FRCPEd, FRCPath, Paul Smith BSc, Phd (auth.)
Ever considering that its discovery in 1742 the carotid physique has remained an organ of poser. initially defined as a ganglion, it was once therefore considered as a gland, chromaffin paraganglion and non-chromaffin paraganglion. In 1928 it used to be proven to be a chemoreceptor with shut institutions with the functionality of baroreception within the adjoining carotid sinus and maybe inside its personal substance. those discoveries led physiologists to embark on a chain of chic experimental reports on a couple of animal species that have, besides the fact that, thus far didn't determine the transducer for detection of adjustments in stress of arterial blood gases or the mechanism of chemor eception. Pathologists nonetheless have principally overlooked the carotid physique, limiting their curiosity to its tumour, the chemodectoma. A striking disparity in wisdom of the organ has resulted, with so much info being to be had at the body structure of chemoreceptor tissue in laboratory animals. against this, there was sparse curiosity and knowledge of the pathology in guy of this nodule of tissue mendacity within the carotid bifurcation whose practical job is advised through the excessive blood circulation it gets, and its wealthy content material of biogenic amines and a wide selection of peptides. This ebook is an try to redress this unsatisfactory state of affairs. over the past few years our figuring out of the precise histology and ultrastructure of the human carotid physique has improved.
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After a period of hypoxia of 24 to 48 hours, numerous mitoses were found in chief cells, whose identification was confirmed on light microscopy by their site and appearance and, in electron micrographs, by their content of dense-core vesicles. Dark Cells in States of Hypoxaemia Virtually no dark cells are found in the carotid bodies for the first 30 weeks of gestation but 35 Fig. 3. Section of carotid body from a male infant of7 months with pulmonary arterial hypoplasia. One of the chief cells contains a mitotic figure (arrow).
Anat Rec 65:8997 de Castro F (1951) Sur la structure de la synapse dans les chemorecepteurs: leur mechanisme d'excitation et role dans la circulation sanguine locale. Acta Physiol Scand 22:14-43 de Kock LL (1954) The intra-glomerular tissues of the carotid body. Acta Anat 21:101-116 Eyzaguirre C, Fidone SJ (1980) Transduction mechanisms in carotid body: glomus cells, putative neurotransmitters, and nerve endings. Am J Physiol 239:CI35-CI52 Eyzaguirre C, Gallego A (1975) An examination of de Castro's original slides.
Combined carotid body weight in young adults with cystic fibrosis and age-matched controls (after Lack et at. 7 CB. D. Average combined CB wt (mg) No. , standard deviation. The Carotid Bodies in Fetuses, Neonates and Infants attributed to this syndrome rather confirming Emery's views that many causes of death were being included in this diagnosis. Naeye (1977) regarded sleep apnoea as the central problem. He thought that important epidemiological features were that the great majority of the infants die while they are supposedly asleep and most of these deaths are silent.
Diseases of the Human Carotid Body by Donald Heath DSc, MD, PhD, FRCP, FRCPEd, FRCPath, Paul Smith BSc, Phd (auth.)