By CIBA Foundation Symposium
T cells are a really good inhabitants of immune cells that relief the immune procedure in battling numerous kinds of invading pathogens. This publication offers up to the moment information at the function of T cells in autoimmune ailments.
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Extra resources for Ciba Foundation Symposium 195 - T Cell Subsets in Infectious and Autoimmune Diseases
5 on cutaneous leishmaniasis in genetically susceptible BALB/c mice. B-17 scid mice with BALB/c T cells initiates a T helper type-1 response and renders them capable of healing Leishmania major infection. Eur J Immunol 23:262-268 DISCUSSION Sher: One might imagine that in most systems T cell responses progress from a T helper 1 (Thl) response to a Th2 response, but not vice versa. Therefore, your inability to revert ThZdominated responses makes sense in terms of this established pattern of T cell differentiation.
It is possible that differences in biodistribution, which depend on the size of the cytokme antagonist, may also be involved. Another complication is that with either antibodies or soluble receptors one may prolong the physical half-life of the cytokine; however, one may or may not prolong the biological half-life of the cytokine. Lotze: Exogenous cytokines, cytokines plus Fc receptors and cytokines plus antibodies are big molecules. Can they get across into tissues? We presume that they can go everywhere throughout the body but this may not be the case.
E. those that will generate Thl cells and a separate, phenotypically distinguishable population that will generate Th2 cells. Mosmann: But we should still not abandon the approaches that Richard Flavell and Richard Locksley were describing. These are elegant methods that are generating valuable information. IL-4 and IFN-y are probably the right cytokines to focus on first because they’re the most specific for those two lineages, but loolung at the other cytokines will also generate valuable information.
Ciba Foundation Symposium 195 - T Cell Subsets in Infectious and Autoimmune Diseases by CIBA Foundation Symposium