Read e-book online Cellular Signaling and Innate Immune Responses to RNA Virus PDF

By Allan R. Brasier, Adolfo García-Sastre, Stanley M. Lemon

ISBN-10: 1555814360

ISBN-13: 9781555814366

ISBN-10: 1555815561

ISBN-13: 9781555815561

A entire survey of the newest discoveries during this field.

  • Provides a platform of information that would result in the improvement of greater tools for controlling the unfold of RNA viruses or editing their illness course.
  • Synthesizes contemporary findings during this fast-moving box whereas additionally reviewing authorized wisdom.
  • Focuses at the antiviral signaling pathways within the host, together with particular trend acceptance receptors and the way those mobile alarms sign the innate immune reaction.
  • Examines the ways that particular significant RNA virus households have interaction with, turn on, and elude those signaling pathways and responses.

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Extra info for Cellular Signaling and Innate Immune Responses to RNA Virus Infections

Example text

Saito, H. Hemmi, O. Ohara, S. Akira, and T. Kaisho. 2006. IkappaB kinase-alpha is critical for interferonalpha production induced by Toll-like receptors 7 and 9. Nature 440:949–953. 46. , P. Georgel, X. Du, L. Shamel, S. Sovath, S. Mudd, M. Huber, C. Kalis, S. Keck, C. Galanos, M. Freudenberg, and B. Beutler. 2005. CD14 is required for MyD88independent LPS signaling. Nat. Immunol. 6:565–570. 47. , T. W. Mak, G. Sen, and X. Li. 2004. Toll-like receptor 3-mediated activation of NF-kappaB and IRF3 diverges at Toll-IL-1 receptor domain-containing adapter inducing IFN-beta.

This implies that IRAK-1 is indeed dispensable for the classical pathway to NF-␬B activation but perhaps plays a role in the noncanonical pathway. Also, it is now believed that IRAK-1 may be more important in TLR signaling pathways to IRF activation (see “TLR7” below). The importance of IRAK-2 in TLR signaling was revealed in a study examining the mechanism whereby A52, a potent vaccinia virus antagonist of TLR signaling to NF-␬B, functioned (35). A52 was found to block NF-␬B activation by multiple human and murine TLRs by binding to IRAK-2.

Chiu, L. Deng, and Z. J. Chen. 2004. TAB2 and TAB3 activate the NF-kappaB pathway through binding to polyubiquitin chains. Mol. Cell 15:535–548. 52. , O. Takeuchi, and S. Akira. 2006. ] Nippon Rinsho 64:1244–1247. 53. , O. Takeuchi, S. Sato, M. Yoneyama, M. Yamamoto, K. Matsui, S. Uematsu, A. Jung, T. Kawai, K. J. Ishii, O. Yamaguchi, K. Otsu, T. Tsujimura, C. S. Koh, 2. Role of TLRs in the Innate Immune Response 54. 55. 56. 57. 58. 59. 60. 61. 62. 63. 64. 65. 66. 67. C. Reis e Sousa, Y. Matsuura, T.

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Cellular Signaling and Innate Immune Responses to RNA Virus Infections by Allan R. Brasier, Adolfo García-Sastre, Stanley M. Lemon


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