Get Cell Death During HIV Infection PDF

By Andrew D. Badley

ISBN-10: 0849328276

ISBN-13: 9780849328275

As a way to transcend immune-based cures, researchers at the moment are contemplating the consequences of apoptosis dysregulation in the course of HIV-induced immunodeficiency. This paintings offers the 1st finished compendium of the development made in knowing the method of phone loss of life on the topic of HIV and the aptitude breakthroughs in remedy that supply a lot promise. Combining the paintings of greater than two-dozen most sensible researchers, this seminal quantity offers clinicians and researchers with a superb reference, whereas additionally serving as an incubator to stimulate destiny learn. It explains the elemental biology concerned with apoptosis, explains its scientific impression in HIV, and examines the latest healing methods.

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For this reason, c-FLIPL shows no cysteine protease activity. 29 FLIPs compete with the caspases for binding to the adaptor FADD. 30 Displacement or inhibition of caspases by FLIPs prevents the onset of the proteolytic caspase cascade and blocks death-receptor-mediated apoptosis. MOLECULAR PATHWAYS OF APOPTOSIS Several stimuli that trigger apoptosis seem to do so by inducing activation of proteolytic enzymes— in particular, but not exclusively, caspases. In order to activate initiator caspases, several molecules of caspase zymogens have to be brought to close proximity to allow self-processing thanks to the moderate catalytic activity of the zymogens.

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S. , Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade, Cell, 91, 479, 1997. 36. , Takio, K. , A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death, Mol. Cell, 8, 613, 2001. 37. , Hashikawa, T. , 11, 208, 2004. 38. , Geuskens, M. , Bcl-2 inhibits the mitochondrial release of an apoptogenic protease, J. Exp. , 184, 1331, 1996. 39. , Penninger, J. , 14, 729, 2000. 40. , Luo, X. , Endonuclease G is an apoptotic DNase when released from mitochondria, Nature, 412, 95, 2001.

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Cell Death During HIV Infection by Andrew D. Badley

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