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By Abelson J.N., Simon M.I., Sies H. (eds.)

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Extra info for Biothiols: Glutathione & Thioredoxin: Thiols in Signal Transduction & Gene Regulation

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4] GLUTATHIONE: DEHYDROASCORBATEOXIDOREDUCTASES 31 Regardless of whether D H A is derived by disproportionation of A A H . 2AAH. ~ DHA + AAH2 or whether A A H 2 reacts with H202 chemically or as a result of ascorbate peroxidase (plant) activity, A A H 2 + H202 -'+ 2 H 2 0 + D H A for normal cellular functions, it is essential to regenerate ascorbic acid from the D H A produced and to maintain a highly reduced A A H 2 / D H A set point. The reduction of D H A by glutathione (GSH), especially at an alkaline pH, is a well-recognized chemical reaction.

Note that these residues accumulate around the active-site selenium (orange ball) in the pleated sheets and turns. (b) Overlay of the bovine cGPX structure and a model of human pGPX. Here the pleated sheets are marked in green, and the cz helices in red. Deviations of the pGPX model from the cGPX structure are shown in yellow. (c) Overlay of the PHGPX model with cGPX. Note the substantial deletion of the random loop and of the small c~ helix left of the active center. FIG. 5. Comparison of the active site structure of bovine cGPX 51 with models of human pGPX and porcine PHGPX.

Note the substantial deletion of the random loop and of the small c~ helix left of the active center. FIG. 5. Comparison of the active site structure of bovine cGPX 51 with models of human pGPX and porcine PHGPX. (a) Active site of cGPX with Arg-57 (lower left comer), Arg-103 (lower right comer) Arg-184 (top), and Arg-185 (upper left comer) in red, Gln-87 in lilac, Trp-165 and Phe-167 in yellow, and selenocysteine in orange. The size of the selenium (big ball) corresponds to its van der Waals radius.

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Biothiols: Glutathione & Thioredoxin: Thiols in Signal Transduction & Gene Regulation by Abelson J.N., Simon M.I., Sies H. (eds.)


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