By Lynne V. McFarland (auth.), Gary W. Elmer, Lynne V. McFarland, Christina M. Surawicz (eds.)
In Biotherapeutic brokers and Infectious illnesses, prime investigators energetic within the discovery, improvement, and alertness of this novel category of anti-infective brokers concisely evaluate using those specific microorganisms in treating human sickness. targeting biotherapeutic entities which have been proven in managed reports, the well-liked specialists light up the clinical underpinnings in their healing strength, check their attainable hazards within the therapy of infectious ailments, and description the learn had to greater outline their effectiveness. additionally, in addition they reflect on biotherapeutic brokers will be genetically engineered for max intestinal and vaginal creation of bioactive components in vivo.
Biotherapeutic brokers and Infectious ailments brings jointly the entire proof had to comprehend and capitalize at the massive promise of this important new classification of biotherapeutic entities. instead to antibiotics that more and more result in drug-resistant pathogens, the dwelling microorganisms defined during this well timed and authoritative ebook will considerably relief cutting-edge clinicians within the prevention and therapy of infectious ailments.
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Lactobacillus casei GG. Bifidobacterium longum. Bifidobacterium bifidum used with Streptococcus thermophilus. Enterococcus faecium SF68. The only yeast species used as biotherapeutic agent is Saccharo- myces boulardii. 3. 1. Mode of Administration Bacterial BTA have been given to patients via three modes of administration: The first mode involves rectal biotherapy inoculates into the rectallumen of a selection of bacterial BTA, but the physiological Mechanisms of Action 29 effects have not been carefully studied.
Regul. 27, 223-229. 17. EImer, G. W. and McFarland, L. V. (1987) Suppression by Saeeharomyees boulardii of toxigenic Clostridium difficile overgrowth after vancomycin treatment in hamsters. Antimicrob. Agents Chemother. 31, 129-131. 18. , EImer, G. , and Levy, R. H. (1989) Disposition kinetics of Saeeharomyees boulardii in man and rat. Biopharm. Drug Dispos. 10, 353-364. 19. Berg, R. D. (1992) Translocation of enteric bacteria in health and disease, in Gut-Derived Infeetious-Toxie Shock (GITS) (Cottier, H.
Fermented milk products or poultices of moldy bread) have been used since antiquity to treat infections, the first scientific description of a biotherapeutic effect was made at the beginning of this century by the Russian Metchnikoff for which he received the Nobel Prize in 1908. Metchnikoff demonstrated that certain species of bacteria were able to enhance the proliferation of Vibrio cholerae, whereas other species inhibited its growth (1). , lactulose effect on the eolonie flora) (2). A "probiotic" or a "biotherapeutie agent" (BTA) is a living mieroorganism administered to promote the health of the host by treating or preventing infections owing to strains of pathogens (3,4).
Biotherapeutic Agents and Infectious Diseases by Lynne V. McFarland (auth.), Gary W. Elmer, Lynne V. McFarland, Christina M. Surawicz (eds.)