By Edward K Wagner; et al
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At the level explored here, it is probably not that useful to expend great efforts to be more definitive about virus origins beyond their functional relationship to the cell and organism they infect. The necessarily close mechanistic relationship between cellular machinery and the genetic manifestations of viruses infecting them makes viruses important biological entities, but it does not make them organisms. They do not grow, they do not metabolize small molecules for energy, and they only “live” when in the active process of infecting a cell and replicating in that cell.
Disease is a common result of the infection, but many (if not most) viral infections result in no measurable disease symptoms – indeed, inapparent infections are often hallmarks of highly co-evolved virus–host interactions. But inapparent or asymptomatic infections can be seen in the interaction between normally virulent viruses and a susceptible host as a result of many factors. A partial list includes the host’s genetic makeup, host health, the degree of immunity to the pathogen in the host, and the random (stochastic) nature of the infective process.
Condit, University of Florida; J. Conway, National Institutes of Health; K. Fish and J. W. Gibson, Johns Hopkins University; P. Ghazal, University of Edinburgh; H. Granzow, Friedrich-Loeffler-Institute – Insel Riems; C. Grose, University of Iowa; J. Hill, Louisiana State University Eye Center – New Orleans; J. Langland, Arizona State University; D. Leib, Washington University; F. Murphy, University of California, Davis; S. Rabkin, Harvard University; S. Rice, University of Alberta–Edmonton; S. Silverstein, Columbia University; B.
Basic virology by Edward K Wagner; et al