New PDF release: Basic Immunology: Functions and Disorders of the Immune

By Abul K. Abbas MBBS, Andrew H. H. Lichtman MD PhD, Shiv Pillai MBBS PhD

ISBN-10: 032339082X

ISBN-13: 9780323390828

In this up-to-date version of Basic Immunology, the authors proceed to convey a transparent, sleek advent to immunology, making this the most obvious selection for latest busy scholars. Their adventure as lecturers, path administrators, and teachers is helping them to distill the center details required to appreciate this complicated box. by utilizing high-quality illustrations, relevant medical situations, and concise, concentrated text, it is a completely accessible creation to the workings of the human immune method, with an emphasis on medical relevance.

  • Concise, clinically targeted content is logically organized through mechanism for effective mastery of the material.
  • Features an appendix of medical cases and CD molecules.
  • Includes numerous full-color illustrations, worthy tables, and chapter outlines.
  • Focus questions within every one bankruptcy are perfect for self-assessment and review.
  • Key points bolded through the textual content make it effortless to find very important information.
  • Presents info in a structure and elegance that maximizes usefulness to scholars and teachers learning medication, allied well-being fields, and biology.
  • Fully up-to-date content equips you with the newest proper advances in immunology.
  • Revised and updated artwork complements your visible studying of vital rules and decreases the over the top real info present in higher textbooks.
  • Twelve brand-new animations to be had on Student Consult aid additional clarify advanced concepts.
  • Student seek advice publication model incorporated with buy. This superior e-book event gives you entry to the textual content, figures, photographs, word list of immunology phrases, self-assessment questions, and references on numerous units.

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Extra info for Basic Immunology: Functions and Disorders of the Immune System, 5e

Sample text

C-reactive protein (CRP) is a pentraxin (five-headed molecule) that binds to phosphorylcholine on microbes and opsonizes the microbes for phagocytosis by macrophages, which express a receptor for CRP. CRP can also activate proteins of the classical complement pathway. The circulating levels of many of these plasma proteins increase rapidly after infection. This protective response is called the acute-phase response to infection. Cytokines of Innate Immunity In response to microbes, dendritic cells, macrophages, mast cells, and other cells secrete cytokines that mediate many of the cellular reactions of innate immunity (Fig.

The components of innate immunity have evolved to recognize structures of microbes that are often essential for the survival and infectivity of these microbes. This characteristic of innate immunity makes it a highly effective defense mechanism because a microbe cannot evade innate immunity simply by mutating or not expressing the targets of innate immune recognition. Microbes that do not express functional forms of these structures lose their ability to infect and colonize the host. In contrast, microbes frequently evade adaptive immunity by mutating the antigens that are recognized by lymphocytes, because these antigens are usually not required for the life of the microbes.

A, NK cells kill host cells infected by intracellular microbes, thus eliminating reservoirs of infection. B, NK cells respond to interleukin-12 (IL-12) produced by macrophages and secrete interferon-γ (IFN-γ), which activates the macrophages to kill phagocytosed microbes. The activation of NK cells is determined by a balance between engagement of activating and inhibitory receptors (Fig. 2-11). The activating receptors recognize cell surface molecules typically expressed on cells infected with viruses and intracellular bacteria, as well as cells stressed by DNA damage and malignant transformation.

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Basic Immunology: Functions and Disorders of the Immune System, 5e by Abul K. Abbas MBBS, Andrew H. H. Lichtman MD PhD, Shiv Pillai MBBS PhD

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