By Yehuda Shoenfeld, Pier Luigi Meroni, M. Eric Gershwin MD
Autoimmune illnesses are characterised by way of the incidence of antibodies reacting with self-constituents of the physique. The absolutely up to date 3rd version of Autoantibodies is an in-depth evaluation of the most autoantibodies pointed out in the past, with specific emphasis on those who reveal a diagnostic or prognostic medical price.
The re-creation covers contemporary medical advances, diagnostic options, and healing applied sciences. every one bankruptcy is concentrated on a unmarried kin of autoantibodies. this significant reference includes ancient notes, definitions, origins and assets of antigens well-known genetic institutions, mediated pathogenic mechanisms, tools of detection, in addition to scientific application (disease occurrence and organization, diagnostic price, sensitivity and specificity, prognostic value). this can be a fantastic reference for somebody excited by the sector of autoimmune illnesses.
- Presents all identified, vital autoantibodies in one resource, concentrating on the antibodies wanted for autoimmune illness diagnosis
- Includes medical functions for every autoantibody in addition to normal information
- Organized by way of sickness and sickness variety, via autoantibody kinfolk, and fully cross-referenced
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Additional info for Autoantibodies
These antigens are recognized by the innate immune system, specifically pathogenic natural IgM clone from B-l, resulting in an acute inflammatory response mediated via the lectin pathway that in the end leads to tissue injury and, if left untreated, tissue necrosis [51–54]. Another explanation for the possible shift in NAbs towards pathogenic autoantibodies might stem from an aberrant presentation of an autoantigen to autoreactive T cells . The idea of causality between NAbs and self-antibodies in autoimmune disorders is further supported by studies demonstrating increased levels of polyreactive B cells in sera of patients with autoimmune disorders [55–61].
In patients with rheumatoid arthritis, the most widely recognized anti-T-cell receptor is of the IgM isotype, whereas in lupus the situation is different and patients’ sera show higher IgG levels binding to a large spectrum of T-cell receptor peptides [68,106]. Atherosclerosis It has been shown that both the innate and adaptive immune systems play a key role in the regulation and modulation of atheromatotic plaques. Accumulating evidence demonstrates the presence of oxidative-specific epitopes, recognized by different receptors on members of the innate immune system, among which are the IgM NAbs.
In addition, 1955 and 1956 were the years of autoimmune thyroiditis: antibodies to thyroglobulin and against the receptor on thyroid cells for natural thyroid-stimulating hormone were reported; it became the prototype for a novel group of autoantibodies that reacted with cell surface receptors with adverse functional effects. Moreover, the presence of autoantibodies in the serum of patients with primary biliary cirrhosis (PBC) was first suggested by Ian Mackay and colleagues in 1958 . These authors found high titers of circulating complement-fixing autoantibodies directed against the liver, kidneys, and other human tissue antigens.
Autoantibodies by Yehuda Shoenfeld, Pier Luigi Meroni, M. Eric Gershwin MD