Autoantibodies - download pdf or read online

By Yehuda Shoenfeld, Pier Luigi Meroni, M. Eric Gershwin MD

ISBN-10: 0444563784

ISBN-13: 9780444563781

Autoimmune illnesses are characterised by way of the incidence of antibodies reacting with self-constituents of the physique. The absolutely up to date 3rd version of Autoantibodies is an in-depth evaluation of the most autoantibodies pointed out in the past, with specific emphasis on those who reveal a diagnostic or prognostic medical price.

The re-creation covers contemporary medical advances, diagnostic options, and healing applied sciences. every one bankruptcy is concentrated on a unmarried kin of autoantibodies. this significant reference includes ancient notes, definitions, origins and assets of antigens well-known genetic institutions, mediated pathogenic mechanisms, tools of detection, in addition to scientific application (disease occurrence and organization, diagnostic price, sensitivity and specificity, prognostic value). this can be a fantastic reference for somebody excited by the sector of autoimmune illnesses.

  • Presents all identified, vital autoantibodies in one resource, concentrating on the antibodies wanted for autoimmune illness diagnosis
  • Includes medical functions for every autoantibody in addition to normal information
  • Organized by way of sickness and sickness variety, via autoantibody kinfolk, and fully cross-referenced

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These antigens are recognized by the innate immune system, specifically pathogenic natural IgM clone from B-l, resulting in an acute inflammatory response mediated via the lectin pathway that in the end leads to tissue injury and, if left untreated, tissue necrosis [51–54]. Another explanation for the possible shift in NAbs towards pathogenic autoantibodies might stem from an aberrant presentation of an autoantigen to autoreactive T cells [16]. The idea of causality between NAbs and self-antibodies in autoimmune disorders is further supported by studies demonstrating increased levels of polyreactive B cells in sera of patients with autoimmune disorders [55–61].

In patients with rheumatoid arthritis, the most widely recognized anti-T-cell receptor is of the IgM isotype, whereas in lupus the situation is different and patients’ sera show higher IgG levels binding to a large spectrum of T-cell receptor peptides [68,106]. Atherosclerosis It has been shown that both the innate and adaptive immune systems play a key role in the regulation and modulation of atheromatotic plaques. Accumulating evidence demonstrates the presence of oxidative-specific epitopes, recognized by different receptors on members of the innate immune system, among which are the IgM NAbs.

In addition, 1955 and 1956 were the years of ­autoimmune thyroiditis: antibodies to thyroglobulin and against the receptor on thyroid cells for natural thyroid-stimulating hormone were reported; it became the prototype for a novel group of autoantibodies that reacted with cell surface receptors with adverse functional effects. Moreover, the presence of ­autoantibodies in the serum of patients with primary biliary cirrhosis (PBC) was first suggested by Ian Mackay and colleagues in 1958 [10]. These authors found high titers of circulating complement-fixing autoantibodies directed against the liver, kidneys, and other human tissue antigens.

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Autoantibodies by Yehuda Shoenfeld, Pier Luigi Meroni, M. Eric Gershwin MD


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