Download PDF by Margaret Ackerman, Falk Nimmerjahn: Antibody Fc. Linking Adaptive and Innate Immunity

By Margaret Ackerman, Falk Nimmerjahn

ISBN-10: 0123948029

ISBN-13: 9780123948021

Antibody Fc is the 1st unmarried textual content to synthesize the literature at the mechanisms underlying the dramatic variability of antibodies to steer the immune reaction. The ebook demonstrates the significance of the Fc area, together with protecting mechanisms, effector telephone kinds, genetic information, and variability in Fc area functionality. This quantity is a severe single-source reference for researchers in vaccine discovery, immunologists, microbiologists, oncologists and protein engineers in addition to graduate scholars in immunology and vaccinology.

Antibodies characterize the correlate of security for various vaccines and are the main quickly transforming into category of gear, with purposes starting from melanoma and infectious disorder to autoimmunity. Researchers have lengthy understood the variable area of antibodies, that are answerable for antigen popularity, and will offer defense via blockading the functionality in their objective antigen. even if, fresh advancements in our knowing of the security mediated through antibodies have highlighted the severe nature of the antibody consistent, or Fc area, within the organic job of antibodies. The Fc area permits antibodies to hyperlink the adaptive and innate immune platforms, supplying specificity to a variety of innate effector cells. additionally, they supply a suggestions loop to manage the nature of the immune reaction through interactions with B cells and antigen-presenting cells.

  • Clarifies the various mechanisms of IgG job on the point of the various version platforms used, together with human genetic, mouse, and in vitro
  • Covers the function of antibodies in melanoma, infectious disorder, and autoimmunity and within the environment of monoclonal antibody treatment in addition to clearly raised antibodies
  • Color illustrations improve factors of the immune system

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Extra resources for Antibody Fc. Linking Adaptive and Innate Immunity

Sample text

Regnault A, Lankar D, Lacabanne V, Rodriguez A, Thery C, Rescigno M, et al. Fcγ receptor-mediated induction of dendritic cell maturation and major histocompatibility complex class I-restricted antigen presentation after immune complex internalization. J Exp Med 1999;189(2):371–80. Rafiq K, Bergtold A, Clynes R. Immune complexmediated antigen presentation induces tumor immunity. J Clin Invest 2002;110(1):71–9. Pearse RN, Feinman R, Ravetch JV. Characterization of the promoter of the human gene encoding the high-affinity IgG receptor: transcriptional induction by γ-interferon is mediated through common DNA response elements.

Dynamic macrophage “probing” is required for the efficient capture of phagocytic targets. J Cell Biol 2010;191(6):1205–18. Zhang Y, Hoppe AD, Swanson JA. Coordination of Fc receptor signaling regulates cellular commitment to phagocytosis. Proc Nat Acad Sci USA 2010;107(45):19332–7. Nagashima H, Ootsubo M, Fukazawa M, Motoi S, Konakahara S, Masuho Y. Enhanced antibodydependent cellular phagocytosis by chimeric monoclonal antibodies with tandemly repeated Fc domains. J Biosci Bioeng 2011;111(4):391–6.

129. Iankov ID, Pandey M, Harvey M, Griesmann GE, Federspiel MJ, Russell SJ. Immunoglobulin G antibody-mediated enhancement of measles virus infection can bypass the protective antiviral immune response. J Virol 2006;80(17):8530–40. 130. Kishimoto C, Kurokawa M, Ochiai H. Antibodymediated immune enhancement in coxsackievirus B3 myocarditis. J Mol Cell Cardiol 2002;34(9):1227–38. 131. Mahalingam S, Lidbury BA. Suppression of lipopolysaccharide-induced antiviral transcription factor (STAT-1 and NF-κB) complexes by antibody-dependent enhancement of macrophage infection by Ross River virus.

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Antibody Fc. Linking Adaptive and Innate Immunity by Margaret Ackerman, Falk Nimmerjahn


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