Download e-book for iPad: Advances in Virus Research, Volume 88 by Karl Maramorosch, Frederick A. Murphy

By Karl Maramorosch, Frederick A. Murphy

ISBN-10: 0128000988

ISBN-13: 9780128000984

The first assessment sequence in virology and released on account that 1953, Advances in Virus Research covers a various variety of in-depth stories, offering a useful evaluate of the sector.

  • Contributions from major authorities
  • Comprehensive stories for basic and expert use
  • First and longest-running overview sequence in virology

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Extra resources for Advances in Virus Research, Volume 88

Sample text

4 Endocytic uptake and intracellular trafficking of DENV particles. Virions attach to molecules on the plasma membrane and start to surf before associating with a preexisting clathrin-coated pit. Upon internalization via clathrin-mediated endocytosis (CME, solid line) or an alternative, yet uncharacterized nonclathrin, noncaveolin, dynamin-dependent endocytic route (dashed line), virions are transported to early endosomes (EE) in a Rab5-dependent manner. 0) triggers a conformational change in E, resulting in hemifusion between the viral envelope and the endosomal membrane (inset B).

The proposed alternative transport of DENV-2 NGC to recycling endosomes (RE) is also represented (dashed line). Revisiting Dengue Virus–Host Cell Interaction 49 membrane during the entry process. With the advent of retrovirus-based reporter viruses pseudotyped with the prM and E proteins of each of the four DENV serotypes, the functional requirement of exposure to low pH for DENV entry has been corroborated. Entry of DENV pseudoparticles (DENVpp) was severely impaired when Huh7 target cells were treated with the lysosomotropic agents ammonium chloride or bafilomycin A during infection (Hu, Hsieh, King, & Wang, 2007), arguing that also authentic DENV particles transit through an acidic compartment prior to fusion.

The assumption that GRP78/BiP acts as a DENV-2 receptor is also supported by a recent study demonstrating that after siRNA-mediated silencing of GRP78/BiP virus, yield and accumulation viral antigen in DENV-infected cells are massively reduced (Alhoot, Wang, & Sekaran, 2012). , 2009). Thus, additional experiments dissecting the functional role of GRP78/BiP during entry and postentry events are required to validate this factor as a putative DENV receptor. , 2004). In this assay, complex protein preparations isolated from plasma membranes of permissive cells are separated according to molecular mass by a single-dimension gel electrophoresis and transferred onto membranes that are probed with purified virus particles.

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Advances in Virus Research, Volume 88 by Karl Maramorosch, Frederick A. Murphy

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