Advances in multiple Sclerosis and Experimental by S. J. Pittock, M. Rodriguez (auth.), Moses Rodriguez (eds.) PDF

By S. J. Pittock, M. Rodriguez (auth.), Moses Rodriguez (eds.)

ISBN-10: 354073676X

ISBN-13: 9783540736769

ISBN-10: 3540736778

ISBN-13: 9783540736776

"There is a necessity for a paradigm shift in our puzzling over the pathogenesis of a number of sclerosis."

Challenging Charcot’s speculation that inflammatory reaction is the first contributor to demyelination, Dr. Rodriguez and associates take a clean, daring examine the motives and attainable remedies of MS.

Assuming oligodendrocyte damage as a prerequisite to MS, the authors discover viruses, pollution and genetic defects as attainable culprits. They current novel easy methods to interrupt and opposite demyelination. This ebook examines the correlation among axonal loss and scientific deficits, together with the implied position of the CD8+ T cellphone and perforin. It assesses proteases, in particular, kallikrein 6, that are strongly linked to lively demyelination. through directing common autoantibodies opposed to oligodendrocytes that exhibit remyelination in animal versions, the authors envision scientific trials for remyelination enhancement.

As across the world famous experts in quite a lot of MS disciplines, the authors discover genetic instruments for picking out sufferers who're probably to adventure spontaneous remyelination. Epidemiology experiences provide extra avenues of remedy. Examples comprise uric acid, statin medicinal drugs, estrogen and progesterone.

MS impacts approximately 400,000 humans within the usa, lots of whom are between18 and forty years of age. With their novel, multifaceted method of easy science—and their purposes in knowing reason and treatment—the authors supply support to clinicians and wish to sufferers.

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Extra resources for Advances in multiple Sclerosis and Experimental Demyelinating Diseases

Example text

Tumefactive MS . . . . . . . . . . . . . . . . . . . . . . . . Balo Concentric Sclerosis . . . . . . . . . . . . . . . . . . . . . Neuromyelitis Optica . . . . . . . . . . . . . . . . . . . . . . 33 34 35 35 36 Conclusions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 38 38 3 4 32 Abstract The last decade has seen a resurgence of interest in MS neuropathology.

The Clinicopathologic Spectrum of CNS Idiopathic Inflammatory Demyelinating Disorders . . . . . . . . . . . . . . . . . . . . . . . . . 5 Acute Disseminated Encephalomyelitis . . . . . . . . . . . . . . . Marburg Variant of Acute MS . . . . . . . . . . . . . . . . . . . Tumefactive MS . . . . . . . . . . . . . . . . . . . . . . . . Balo Concentric Sclerosis . . . . . . . . .

Neurology 46:907–911 43. McAlpine D (1964) The benign form of multiple sclerosis: Results of a long-term study. BMJ 2:1029–1032 44. McAlpine D, Compston N (1952) Some aspects of the natural history of disseminated sclerosis. Q J Med 21:135–167 45. Minneboo A, Uitdehaag B, Ader H, Barkhof F, Polman C, Castelijins J (2005) Patterns of enhancing lesion evolution in multiple sclerosis are uniform within patients. Neurology 65:56–61 46. Myhr K, Riise T, Vedeler C, Nortvedt MW, Gronning R, Midgard R, Nyland HI (2001) Disability and prognosis in multiple sclerosis: demographic and clinical variables important for the ability to walk and awarding of disability pension.

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Advances in multiple Sclerosis and Experimental Demyelinating Diseases by S. J. Pittock, M. Rodriguez (auth.), Moses Rodriguez (eds.)


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