By George F. Vande Woude, George Klein
Advances in melanoma examine offers important details at the intriguing and fast-moving box of melanoma examine. right here once more, amazing and unique stories are awarded. Key positive aspects * The Yin Yang of TCF/b-Catenin Signalling * Biochemical and scientific Implications of the Erb/HER Signaling community of development issue Receptors * p53 and Human melanoma: the 1st 10000 Mutations * Macrophage Stimulating Protein * CD44 Glycoproteins in Colorectal melanoma; Expression; functionality; and Prognostic worth * an easy Modes for Carcinogenesis of Colorectal melanoma with Microsatellite Instability
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Extra info for Advances in Cancer Research, Vol. 77
44 Leah N. Klapper et al. cancer has been most convincingly demonstrated for TGF-␣. , 1989) malignancies. , 1993a). Enhanced synthesis of EGF has been reported in several tumors, including lung and ovarian tumors and the levels of both growth factors were found to be elevated in the urine of glioma patients. , 1998). Neuregulins (NRGs) comprise an additional group of ErbB activating proteins, demonstrating a speciﬁcity of binding toward ErbB-3 and ErbB-4 (Burden and Yarden, 1997). , 1992), inhibits terminal differentiation and induces adenocarcinomas when targeted to the mammary gland of transgenic mice (Krane and Leder, 1996), suggesting involvement in tumor-propagating processes mediated by ErbB receptors.
HOW DOES ErbB-2 INDUCE CANCER? A. In Vitro Transforming Potential of ErbB-2 How ErbB-2 causes cancer is a question that has been repeatedly asked— and the answers reevaluated—during the past 15 years. Its role in cellular transformation, insinuated by its abundance in a wide range of human tumors, is supported by a few but solid lines of evidence that therapies directed against this receptor can indeed impede tumor growth. , 1991). , 1987), indicating that a threshold level of overexpression is crucial for its oncogenic potential.
Prostate Cancer D. Gastrointestinal Cancer E. Lung Cancer F. Head and Neck Cancer G. Kidney Cancer H. Bladder Cancer I. Brain Tumors III. How Does ErbB-2 Induce Cancer? A. In Vitro Transforming Potential of ErbB-2 B. ErbB Activating Ligands C. Does ErbB-2 Have a Ligand of Its Own? D. Ligand-Independent Receptor Dimerization IV. Evolutionary and Developmental Aspects of the Multiplicity of ErbB Proteins V. The ErbB Signaling Network A. Evidence for Inter-Receptor Interactions B. Transforming Ability of Heterodimers C.
Advances in Cancer Research, Vol. 77 by George F. Vande Woude, George Klein